Islet-1 / Unconjugated / 1H9
Product Details
| Description | ISL1 encodes islet 1, a transcription factor containing two amino-terminal LIM domains and one carboxy-terminal homeodomain. ISL1 plays an important role in the embryogenesis of pancreatic islets of Langerhans. In addition, mouse embryos made deficient in ISL1 fail to undergo neural tube motor neuron differentiation. | |
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| Conjugate | Unconjugated | |
| Clone | 1H9 | |
| Target Species | Human | |
| Applications | ELISA, IF, IHC-P, WB | |
| Supplier | Aviva Systems Biology | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About Islet-1
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
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