Sclerostin / Unconjugated /

Product Details
Description SOST Antibody (OACD07429) Unconjugated Rabbit Polyclonal Antibody, Reacts with Mouse
Conjugate Unconjugated
Clone
Target Species Mouse
Applications ELISA, IHC-P, ICC, WB, IHC-Fr
Supplier Aviva Systems Biology
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About Sclerostin
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
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