TRPM4 / Unconjugated /
Product Details
| Description | TRPM4 and its close homologue TRPM5 are the two only members of the large TRP superfamily of cation channels that are impermeable to Ca(2+). TRPM4, undergoes a fast desensitization to Ca(2+). The Ca(2+) sensitivity of TRPM4 is regulated by ATP, PKC-dependent phosphorylation, and calmodulin binding at the C-terminus. TRPM4-mediate depolarization modulates Ca2+ oscillations, with downstream effects on cytokine production in T lymphocytes. | |
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| Conjugate | Unconjugated | |
| Clone | ||
| Target Species | Mouse | |
| Applications | IHC-P | |
| Supplier | Aviva Systems Biology | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About TRPM4
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]
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