SRPK1 / Unconjugated / 6H5

Product Details

Description	SRPK1, an SRPK serine/threonine protein kinase, phosphorylates SR proteins (splicing factors) which are arranged in speckles in the nucleus during mitosis, and thereby the receptor affects spliceosome assembly and distribution. SRPK1 has also been found to modify the lamin B receptor, an integral protein of inner nuclear membrane. The SRPK1 gene is involved in cisplatin-induced cell killing and can therefore confer drug resistance (Schenk et al., 2001).
Conjugate	Unconjugated
Clone	6H5
Target Species	Human
Applications	ELISA, IHC-P, WB
Supplier	Aviva Systems Biology
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About SRPK1
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]

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