UBE2D1 / Unconjugated /

Product Details
Description UBE2D1 Antibody (OAGA03366) Unconjugated Rabbit Polyclonal Antibody, Reacts with Human, Mouse
Conjugate Unconjugated
Clone
Target Species Human, Mouse
Applications IF, IHC-P, ICC, WB
Supplier Aviva Systems Biology
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About UBE2D1
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
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