PDE1C / Unconjugated /
Product Details
| Description | Phosphodiesterase 1C is a cAMP/cGMP dual-specific, calcium/calmodullin-dependent phosphodiesterase. PDE1C has been shown to affect vascular smooth muscle proliferation and atherosclerosis, insulin secretion regulation, spermatozoa development, and erectile dysfunction. At least five PDE1C isoforms have been reported, the expression of which are regulated in a tissue/cell-specific manner. | |
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| Conjugate | Unconjugated | |
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| Target Species | Bat, Bovine, Canine, Equine, Gibbon, Gorilla, Hamster, Human, Monkey, Mouse, Orangutan, Rabbit, Rat | |
| Applications | IHC-P | |
| Supplier | Aviva Systems Biology | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About PDE1C
This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
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