PDE11A / Unconjugated /
Product Details
| Description | Phosphodiesterase 11A is a cAMP/cGMP dual-specific phosphodiesterase. PDE11A activity is inhibited by IBMX, as well as zaprinast and dipyridamole. At least four isoforms have been identified which carry distinct GAF sequences in the N-terminal regions. PDE11A2 contains an additional 86 amino acids at the N-terminus. PDE11A3 contains an additional 108 N-terminal amino acids compared to PDE11A2. PDE11A4 is the longest isoform. | |
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| Conjugate | Unconjugated | |
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| Target Species | Bat, Bovine, Chicken, Equine, Gibbon, Gorilla, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Zebrafish | |
| Applications | IHC-P | |
| Supplier | Aviva Systems Biology | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About PDE11A
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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