DDR2 / Unconjugated /
Product Details
| Description | DDR2 is a DDR/TKT type protein kinase. The protein has a unique extracellular region encompassing a factor VIII-like domain. Like DDR1, DDR2 is activated by various types of collagen, and binding of collagen to DDR2 protein results in a delayed but sustained tyrosine kinase activation. DDR2 may function as an extracellular matrix sensor to modulate cell proliferation. | |
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| Conjugate | Unconjugated | |
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| Target Species | Human | |
| Applications | ELISA, IF, IHC-P, WB | |
| Supplier | Aviva Systems Biology | |
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About DDR2
This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]
This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]
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