CEP78 / Unconjugated /

Product Details
Description CEP78 Antibody - middle region (OASG01487) Unconjugated Rabbit Polyclonal Antibody, Reacts with Human, Mouse
Conjugate Unconjugated
Clone
Target Species Human, Mouse
Applications ELISA, WB, IHC
Supplier Aviva Systems Biology
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About CEP78
This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients. [provided by RefSeq, Mar 2017]
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