GSKIP / Unconjugated / 2F2

Product Details
Description C14ORF129 Antibody (OAAL00690) Unconjugated Mouse Monoclonal Antibody, Reacts with Human
Conjugate Unconjugated
Clone 2F2
Target Species Human
Applications ELISA, IF, WB
Supplier Aviva Systems Biology
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About GSKIP
This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
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