HIF-2 alpha / ATTO 655 / EP190B

Product Details

Description	Mouse monoclonal to HIF2 alpha (ATTO 655). Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. HIF2-Alpha is involved in catecholamine homeostasis, vascular remodeling, physiological angiogenesis and adipogenesis. It is overexpressed in many cancerous tissues, but its exact role in tumour progression remains to be clarified. Studies suggest that in the case of non-small cell lung cancer, HIF2-Alpha actually is a promoter of tumor growth and progression in a solid tumor. Other data suggests that HIF2-Alpha is an important regulator of innate immunity, and therefore may be useful in the therapeutic target for treating inflammatory disorders and cancer..
Conjugate	ATTO 655
Clone	EP190B
Target Species	Human
Applications	ELISA, IF, IHC-P, ICC, WB
Supplier	Biorbyt
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About HIF-2 alpha
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]

About ATTO 655
ATTO 655 from ATTO-Tec Gmbh has an excitation peak at 663 nm and an emission peak at 684 nm.

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