TEC / Unconjugated /

Product Details

Description	Rabbit polyclonal antibody to Tec. Tec is a member of the Tec family of non-receptor protein-tyrosine kinase (PTK) which also includes Btk, emtk/itk/Tsk, Rlk/Txx and Bmx. Tec is composed of a pleckstrin domain (PH), an SH3 and SH2 domain, a catalytic kinase domain and a Tec homology domain (TH). Tecs TH domain interacts with the SH3 domain of Grb2, Src family PTKs ( Fyn, Lyn, and Hck), Vav, and c-Kit. Tec is mostly expressed in hematopoietic cells. Tecs SH3 domain interacts with DC28 and has been shown to phosphorylate p62 dok, CD28 substrate. Tec can phosphorylate Jak kinase in hematopoietic cellsand can also be phosphorylated by Src member Lyn on multiple tyrosine residues.
Conjugate	Unconjugated
Clone
Target Species	Human, Mouse, Rat
Applications	WB
Supplier	Biorbyt
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About TEC
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

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