ABCC8 / Unconjugated / S289-16

Product Details
Description Mouse Monoclonal Anti-SUR1 Antibody
Conjugate Unconjugated
Clone S289-16
Target Species Hamster, Mouse, Rat
Applications IF, WB, IHC
Supplier OriGene
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About ABCC8
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations in the ABCC8 gene and deficiencies in the encoded protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]
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251 ABCC8 antibodies from over 19 suppliers available with over 42 conjugates.

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