RASD2 / Unconjugated / OTI1G1
Product Details
| Description | RASD2 mouse monoclonal antibody, clone OTI1G1 (formerly 1G1) | |
|---|---|---|
| Conjugate | Unconjugated | |
| Clone | OTI1G1 | |
| Target Species | Canine, Human | |
| Applications | FC, WB, IHC | |
| Supplier | OriGene | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About RASD2
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
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220 RASD2 antibodies from over 14 suppliers available with over 46 conjugates.
