PIAS3 / Unconjugated /

Product Details

Description	Rabbit polyclonal to PIAS3.Protein inhibitor of activated STAT3 (PIAS3) is a member of the PIAS proteins. The mammalian PIASfamily is composed of four proteins: PIAS1, PIAS2 (PIASx), PIAS3, and PIAS4 (PIASy). PIAS proteinsfunction as E3 small ubiquitin-like modifier (SUMO) ligases, which facilitate the conjugation of SUMOto the specific protein substrates. PIAS3 has been shown to play important roles in the transcriptionalregulation of various cellular pathways, including STAT, SMAD and the steroid hormone signalingpathways. The effects of this transcriptional co-regulation, transactivation or silencing, may varydepending upon the biological context.
Conjugate	Unconjugated
Clone
Target Species	Human, Mouse
Applications	WB
Supplier	Biorbyt
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About PIAS3
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

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