Pannexin 2 / ATTO 594 / S121A-31

Product Details

Description	Mouse monoclonal to Pannexin 2 (ATTO 594). Gap junctions are formed by a hexameric group of proteins called connexions for the transport of low molecular weight proteins from cell to cell. Connexins, which are present in all metazoan organisms, serve diverse functions ranging from control of cell growth and differentiation to electric conduction in excitable tissues. Several mammalian cells with malignant phenotypes exhibit decreased connexin expression and gap junction communication. The pannexin gene family encodes a second class of putative gap junction proteins. Pannexins are highly conserved in invertebrates and mammals, indicating the importance of their gap junctional coupling function. Mammalian Pannexin-1 and Pannexin-3 are closely related, while Pannexin-2 is more distantly related. Pannexin-2 is a transmembrane protein expressed in the central nervous system that is unable to assemble in homomeric channels but forms heteromeric channels with Pannexin-1..
Conjugate	ATTO 594
Clone	S121A-31
Target Species	Rat
Applications	IHC-P, WB
Supplier	Biorbyt
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About Pannexin 2
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

About ATTO 594
ATTO 594 from ATTO-Tec Gmbh has an excitation peak at 601 nm and an emission peak at 627 nm.

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