Osteocalcin / Unconjugated /
Product Details
| Description | Rabbit polyclonal antibody to osteocalcin is the most abundant non-collagenous protein in bone, comprising almost 2% of total protein in the human body. It is important in bone metabolism and is used as a clinical marker for bone turnover, but its precise function remains elusive. With no known enzyme activity, osteocalcin's function depends on its structure. That structure has now been determined by X-ray crystallography, to reveal a negatively charged protein surface that places five calcium ions in positions complementary to those in hydroxyapatite, an important mineral component of bone. Using this recognition mechanism, osteocalcin could potentially modulate the crystal morphology and growth of hydroxyapatite. And in this complex, the carboxy terminus of osteocalcin, which promotes the adhesion of osteoblasts and osteoclasts in bone replacement, is readily accessible. | |
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| Conjugate | Unconjugated | |
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| Target Species | Human, Mouse, Rat | |
| Applications | ELISA, IHC-P, WB | |
| Supplier | Biorbyt | |
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About Osteocalcin
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
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700 Osteocalcin antibodies from over 20 suppliers available with over 42 conjugates.
