Nav1.8 / ATTO 633 / S134-12

Product Details

Description	Mouse monoclonal to Nav1 (ATTO 633). 8. Nav1. 8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1. 8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1. 8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals..
Conjugate	ATTO 633
Clone	S134-12
Target Species	Human, Rat
Applications	IF, IHC-P, ICC, WB
Supplier	Biorbyt
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About Nav1.8
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

About ATTO 633
ATTO 633 from ATTO-Tec Gmbh has an excitation peak at 629 nm and an emission peak at 657 nm.

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