NALCN / Unconjugated / S187-7

Product Details
Description Mouse monoclonal to NALCN.NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-likeprotein 1), is a 1738 amino acid multi-pass membraneprotein that belongs to the cation-nonselective channelfamily. NALCN is highly conserved in mammals and iswidely expressed in the central nervous system.Activated by NK-1R, NALCN is a voltage-independent,nonselective cation channel which is permeable tosodium, potassium and calcium ions. NALCN isresponsible for background sodium ion leak conductancein neurons and regulates basal excitability of the nervoussystems. Defects of NALCN in mice causes disruption inrespiratory rhythm and death occurs within 24 hours ofbirth. Three isoforms of NALCN exists due to alternativesplicing events.
Conjugate Unconjugated
Clone S187-7
Target Species Rat
Applications IF, ICC, WB
Supplier Biorbyt
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About NALCN
This gene encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodium leak current that contributes to tonic neuronal excitability. The encoded protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in this gene are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth. [provided by RefSeq, Apr 2017]
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