MEST / Unconjugated /

Product Details

Description	Rabbit polyclonal antibody to MEST, which is also known as EC 3 and PEG1. It is frequently found in the plasma membrane and is expressed in the ovarian mesenchymal stroma cells and duct progenitor cells. It is overexpressed in the omentum and adrenal gland. Mesoderm-specific transcript protein expressed in fetal tissues from the paternal chromosome and in hydatidiform mole of androgenic origin is identical to the murine imprinted gene Peg1 and unlikely to be a contributor to Silver-Russell syndrome with aberrant imprinting in invasive breast carcinomas.
Conjugate	Unconjugated
Clone
Target Species	Human, Mouse, Rat
Applications	ELISA, IF, IHC-P, ICC, WB
Supplier	Biorbyt
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About MEST
This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

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