KDM4B / Unconjugated /

Product Details

Description	Rabbit polyclonal to KDM4B.Lysine-specific demethylase 4B (KDM4B) is a histone demethylase that specifically demethylates'Lys-9' of histone H3, thereby playing a role in histone code. KDM4B does not demethylate histone H3'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. KDM4B only demethylates trimethylated H3 'Lys-9',and it has a weaker activity than KDM4A, KDM4C and KDM4D.
Conjugate	Unconjugated
Clone
Target Species	Human
Applications	WB
Supplier	Biorbyt
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About KDM4B
Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer. [provided by Alliance of Genome Resources, Apr 2022]

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