JMJD6 / Unconjugated /

Product Details

Description	Rabbit polyclonal to JMJD6.Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is a dioxygenase that can both act asa histone arginine demethylase and a lysyl-hydroxylase. JMJD6 is required for differentiation ofmultiple organs during embryogenesis. It acts as a key regulator of hematopoietic differentiation: it isrequired for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65.JMJD6 seems to be necessary for the regulation of macrophage cytokine responses.
Conjugate	Unconjugated
Clone
Target Species	Human
Applications	WB
Supplier	Biorbyt
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About JMJD6
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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