INO80 / Unconjugated /

Product Details

Description	Rabbit polyclonal to INO80.DNA helicase INO80 is a main scaffold component of the chromatin remodeling INO80 complexinvolved in transcriptional regulation, DNA replication and probably DNA repair. The involvement ofINO80 in DNA double-strand break repair appears to be largely indirect through transcriptionalregulation. INO80 is recruited by YY1 to YY1-activated genes, where it binds to DNA and acts as anessential coactivator. INO80 has double stranded DNA-dependent ATPase activity in vitro. INO80 isinvolved in UV-damage excision repair, DNA replication and chromosome segregation during normalcell division cycle.
Conjugate	Unconjugated
Clone
Target Species	Human, Mouse
Applications	WB
Supplier	Biorbyt
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About INO80
This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

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