CTH / Unconjugated /

Product Details

Description	Rabbit Polyclonal to CTH. CTH(CYSTATHIONINE GAMMA-LYASE),also called CYSTATHIONASE, is an enzyme which breaks down cystathionine into cysteine and alpha-ketobutyrate.And the CTH gene is mapped on 1p31.1. In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide and that genetic deletion of this enzyme in mice markedly reduced H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CTH displayed pronounced hypertension and diminished endothelium-dependent vasorelaxation. Cystathionine was physiologically activated by calcium and calmodulin, which is a mechanism for H2S formation in response to vascular activation.
Conjugate	Unconjugated
Clone
Target Species	Human, Rat
Applications	IF, IHC-P, ICC, WB, IHC-Fr
Supplier	Biorbyt
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About CTH
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

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