CCR7 / Unconjugated /

Product Details

Description	Rabbit polyclonal to CCR7.C-C chemokine receptor type 7 (CCR7) is a receptor for the MIP-3-beta chemokine and belongs tothe G-protein coupled receptor 1 family. CCR7 was identified as a gene induced by the Epstein-Barrvirus (EBV) and is a probable mediator of EBV effects on B-lymphocytes as well as of normallymphocyte functions. CCR7 is expressed in various lymphoid tissues and activates B and Tlymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as wellas to stimulate dendritic cell maturation. CCR7 is strongly up-regulated in B-cells infected withEpstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
Conjugate	Unconjugated
Clone
Target Species	Human
Applications	WB
Supplier	Biorbyt
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About CCR7
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

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