BARD1 / Unconjugated /

Product Details

Description	Rabbit polyclonal to BARD1.BRCA1-associated RING domain protein 1 (BARD1) is a probable E3 ubiquitin-protein ligase and atumor suppressor. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNAdamage repair, ubiquitination and transcriptional regulation to maintain genomic stability. BARD1plays a central role in the control of the cell cycle in response to DNA damage. It also forms aheterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibitingpre-mRNA 3' cleavage.
Conjugate	Unconjugated
Clone
Target Species	Human
Applications	WB
Supplier	Biorbyt
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About BARD1
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

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