53BP1 / Unconjugated /

Product Details
Description Rabbit polyclonal to 53BP1
Conjugate Unconjugated
Clone
Target Species Human, Mouse, Rat
Applications ELISA, IF, IHC-P, ICC
Supplier Biorbyt
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About 53BP1
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
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